Canal arterial
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Canal arterial
Mantenham-se atentos. O paracetamol parece, à semelhança do ibuprofeno, ser útil no encerramento do PDA
Pediatrics. 2011 Nov 7.
Ductal Closure with paracetamol: A Surprising new approach to PDA treatment
Hammerman C, Bin-Nun A, Markovitch E, Schimmel MS, Kaplan M, Fink D
Standard pharmacologic closure of the patent ductus
arteriosus currently involves the administration of 1 of 2
cyclooxygenase inhibitors: either indomethacin or ibuprofen. However,
both of these drugs can be associated with potentially significant
adverse effects. We present here the cases of 5 preterm infants
(gestational age: 26-32 weeks; postnatal age: 3-35 days) with large,
hemodynamically significant patent ductus
arteriosus who had either failed or had contraindications to ibuprofen
therapy. Each of these infants was treated with off-label oral paracetamol
(15 mg/kg per dose every 6 hours). Ductal closure was achieved within
48 hours in all the treated infants. No toxicity was observed.
PMID: 22065264
Pediatrics. 2011 Nov 7.
Ductal Closure with paracetamol: A Surprising new approach to PDA treatment
Hammerman C, Bin-Nun A, Markovitch E, Schimmel MS, Kaplan M, Fink D
Standard pharmacologic closure of the patent ductus
arteriosus currently involves the administration of 1 of 2
cyclooxygenase inhibitors: either indomethacin or ibuprofen. However,
both of these drugs can be associated with potentially significant
adverse effects. We present here the cases of 5 preterm infants
(gestational age: 26-32 weeks; postnatal age: 3-35 days) with large,
hemodynamically significant patent ductus
arteriosus who had either failed or had contraindications to ibuprofen
therapy. Each of these infants was treated with off-label oral paracetamol
(15 mg/kg per dose every 6 hours). Ductal closure was achieved within
48 hours in all the treated infants. No toxicity was observed.
PMID: 22065264
Gabriela Mimoso- Mensagens : 12
Data de inscrição : 29/09/2011
Localização : Coimbra
Local de trabalho : Maternidade Bissaya Barreto em breve Centro Hospitalar e Universitário de Coimbra
Re: Canal arterial
Excelente notícia! Para os prematuros e principalmente para um país em crise!
Fernando Graça- Mensagens : 1
Data de inscrição : 05/01/2012
Local de trabalho : Centro Hospitalar Alto Ave - Guimarães
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